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Cleistanthus collinus

Cleistanthus collinus[2] is a plant species first described by Roxburgh, with its current name after Bentham and Hooker; it is included in the family Phyllanthaceae.[3][4] The IUCN categorizes this species as vulnerable.[1] No subspecies are listed in the Catalogue of Life.[3]

Cleistanthus collinus
Cleistanthus collinus (Garari) in Narsapur forest, AP W IMG 0165.jpg
Scientific classification
C. collinus
Binomial name
Cleistanthus collinus

Lebidieropsis orbiculata var. lambertii
Lebidieropsis orbiculata var. collina
Lebidieropsis orbiculata (Roth) Müll.Arg.
Lebidieropsis collina (Roxb.) Müll.Arg.
Emblica palasis Buch.-Ham.
Bridelia collina (Roxb.) Hook. & Arn.
Andrachne orbiculata Roth
Andrachne cadishaco Roxb. ex Wall.
Amanoa collina (Roxb.) Baill.


Cleistanthus collinus (Karra) contains a plant poison also called oduvan (Tamil), kadise (Kannada), Vadisaku (Telugu) and Oduku (Malayalam). Ingestion of its leaves or a decoction of its leaves causes hypokalemia (kaliuresis and cardiac arrhythmias),[5] metabolic acidosis, hypotension and hypoxia[6] probably due to distal renal tubular acidosis, ARDS and toxin induced vasodilatation respectively.[7][8][9] Hypokalemia and acidosis probably also induces rhabdomyolysis resulting in myoglobinuric renal failure and neuromuscular weakness.[10] Its effects are probably mediated by injury to the distal renal tubules, pulmonary epithelium and peripheral blood vessels due to glutathione depletion[11] (animal studies have shown benefit with N-acetylcysteine).[12]

Cleistanthin A and cleistanthin B are phytoconstituents of C. collinus. Cleistanthin A and cleistanthin B are arylnaphthalide lignans. They have been reported to be toxic substances responsible for poisoning. Cleistanthin A is also present in Phyllanthus taxodiifolius.[13]



  1. ^ a b World Conservation Monitoring Centre (1998). "Cleistanthus collinus". The IUCN Red List of Threatened Species. IUCN. 1998: e.T34271A9855293. doi:10.2305/IUCN.UK.1998.RLTS.T34271A9855293.en. Retrieved 27 December 2017.
  2. ^ Benth. ex Hook.f., 1887 In: Fl. Brit. India 5: 274
  3. ^ a b Roskov Y.; Kunze T.; Orrell T.; Abucay L.; Paglinawan L.; Culham A.; Bailly N.; Kirk P.; Bourgoin T.; Baillargeon G.; Decock W.; De Wever A. (2014). Didžiulis V., ed. "Species 2000 & ITIS Catalogue of Life: 2014 Annual Checklist". Species 2000: Reading, UK. Retrieved 26 May 2014.
  4. ^ WCSP: World Checklist of Selected Plant Families
  5. ^ Thomas, K; Dayal, AK; Narasimhan, Alka G; Seshadri, MS; Cherian, AM; Kanakasabapathi, Molly B (1991). "Metabolic and Cardiac effects of Cleistanthus Collinus poisoning". J Assoc Physicians India. 39 (4): 312–314.
  6. ^ Subrahmanyam, DK; Mooney, T; Raveendran, R; Zachariah, B. A (Nov 2003). "Clinical and laboratory profile of Cleistanthus collinus poisoning". J Assoc Physicians India. 51: 1052–4.
  7. ^ Eswarappa, S.; Chakraborty, A R; Palatty, B U; Vasnik, M (2003). "Cleistanthus Collinus Poisoning: Case Reports and Review of the Literature". Clinical Toxicology. 41 (4): 369–72. doi:10.1081/clt-120022005.
  8. ^ Benjamin SPE, M Edwin Fernando, JJ Jayanth, Preetha B; Cleistanthus collinus poisoning. J Assoc Physicians India 2006 Sep; 54:742-44
  9. ^ Nampoothiri, K; Chrispal, A; Begum, A; Jasmine, S; Gopinath, KG; Zachariah, A (Mar 2010). "A clinical study of renal tubular dysfunction in Cleistanthus collinus (Oduvanthalai) poisoning". Clin Toxicol. 48 (3): 193–7. doi:10.3109/15563651003641786. PMC 2875161.
  10. ^ Eswarappa, Benjamin SPE (Jan 2007). "Renal failure and neuromuscular weakness in Cleistanthus collinus poisoning". J Assoc Physicians India. 55: 85–86.
  11. ^ Sarathchandra, G; Balakrishnamoorthy, P. "Acute toxicity of Cleistanthus collinus, an indigenous poisonous plant in Cavia procellus". Journal of Environmental Biology. 1998: 145–8.
  12. ^ Annapoorani, KS; Damodaran, C; Chandrasekharan, P (1986). "A promising antidote to Cleistanthus collinus poisoning". J Sci Soc Ind. 2: 3–6.
  13. ^ Parasuraman, S; Raveendran, R (2012). "Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats". J Young Pharm. 4: 73–7. doi:10.4103/0975-1483.96616. PMC 3385220. PMID 22754257.