Classical genetics is the branch of genetics based solely on visible results of reproductive acts. It is the oldest discipline in the field of genetics, going back to the experiments on Mendelian inheritance by Gregor Mendel who made it possible to identify the basic mechanisms of heredity. Subsequently, these mechanisms have been studied and explained at the molecular level.
Classical genetics consists of the techniques and methodologies of genetics that were in use before the advent of molecular biology. A key discovery of classical genetics in eukaryotes was genetic linkage. The observation that some genes do not segregate independently at meiosis broke the laws of Mendelian inheritance, and provided science with a way to map characteristics to a location on the chromosomes. Linkage maps are still used today, especially in breeding for plant improvement.
After the discovery of the genetic code and such tools of cloning as restriction enzymes, the avenues of investigation open to geneticists were greatly broadened. Some classical genetic ideas have been supplanted with the mechanistic understanding brought by molecular discoveries, but many remain intact and in use. Classical genetics is often contrasted with reverse genetics, and aspects of molecular biology are sometimes referred to as molecular genetics.
At the base of classical genetics is the concept of a gene, the hereditary factor tied to a particular simple feature (or character).
Classical genetics is the part of genetics that is solely about the method in which genetic traits are transmitted via the acts of reproduction. Genetics is, generally, the study of genes, genetic variation, and heredity. The process by which characteristics are passed down from parents to their offspring is called heredity. In the sense of classical genetics, variation is known as the lack of resemblance in related individuals and can be categorized as discontinuous or continuous. Genes are a fundamental part of DNA that is aligned linearly on a eukaryotic chromosome. Chemical information that is transported and encoded by each gene is referred to as a trait. Many organisms possess two genes for each individual trait that is present within that particular individual. These paired genes that control the same trait is classified as an allele. In an individual, the allelic genes that are expressed can be either homozygous, meaning the same, or heterozygous, meaning different. Many pairs of alleles have differing effects that are portrayed in an offspring's phenotype and genotype. The phenotype is a general term that defines an individual's visible, physical traits. The genotype of an offspring is known as its genetic makeup. The alleles of genes can either be dominant or recessive. A dominant allele needs only one copy to be expressed while a recessive allele needs two copies (homozygous) in a diploid organism to be expressed. Dominant and recessive alleles help to determine the offspring’s genotypes, and therefore phenotypes.
and began with Gregor Mendel's experiments that formulated and defined a fundamental biological concept known as Mendelian Inheritance. Mendelian Inheritance is the process in which genes and traits are passed from a set of parents to their offspring. These inherited traits are passed down mechanistically with one gene from one parent and the second gene from another parent in sexually reproducing organisms. This creates the pair of genes in diploid organisms. Gregor Mendel started his experimentation and study of inheritance with phenotypes of garden peas and continued the experiments with plants. He focused on the patterns of the traits that were being passed down from one generation to the next generation. This was assessed by test-crossing two peas of different colors and observing the resulting phenotypes. After determining how the traits were likely inherited, he began to expand the amount of traits observed and tested and eventually expanded his experimentation by increasing the number of different organisms he tested.
About 150 years ago, Gregor Mendel published his first experiments with the test crossing of Pisum peas. Seven different phenotypic characteristics were studied and tested in the peas, including seed color, flower color and seed shape. Mendel took peas that had differing phenotypic characteristics and test-crossed them to assess how the parental plants passed the traits down to their offspring. He started by crossing a round, yellow and round, green pea and observed the resulting phenotypes. The results of this experiment allowed him to see which of these two traits was dominant and which was recessive based upon the number of offspring with each phenotype. Mendel then chose to further his experiments by crossing a pea plant homozygous dominant for round and yellow phenotypes with a pea plant that was homozygous recessive for wrinkled and green. The plants that were originally crossed are known as the parental generation, or P generation, and the offspring resulting from the parental cross is known as the first filial, or F1, generation. The plants of the F1 generation resulting from this hybrid cross were all heterozygous round and yellow seeds.
Classical genetics is a hallmark of the start of great discovery in biology, and has led to increased understanding of multiple important components of molecular genetics, human genetics, medical genetics, and much more. Thus, reinforcing Mendel's nickname as the father of modern genetics.
- Classical and Molecular Genetics. ISBN 9781631817762.
- Lagassé, Paul; University, Columbia (January 2000). Genetics. ISBN 9780787650155.
- "Mendelian Genetics - Genetics Generation". Genetics Generation. Retrieved 2017-11-29.
- Mendel, Gregor. "Experiments in Plant Hybridization (1865) - Mendel's Paper (English - Annotated)". www.mendelweb.org. Retrieved 2017-11-29.
- "Centenary of Mendel's Paper". British Medical Journal. 1 (5431): 368–374. 1965-02-06. ISSN 0007-1447. PMC 2165333. PMID 14237908.
- Van Dijk, Peter J.; Ellis, T. H. Noel (2016). "The Full Breadth of Mendel's Genetics". Genetics. 204 (4): 1327–1336. doi:10.1534/genetics.116.196626. PMC 5161265. PMID 27927898.
- "Mendel and his peas". Khan Academy. Retrieved 2017-11-29.
- Leland., Hartwell (2014-09-05). Genetics : from genes to genomes. Goldberg, Michael L., Fischer, Janice A. (Fifth ed.). New York, NY. ISBN 978-0073525310. OCLC 854285781.
- "dihybrid cross / dihybrid | Learn Science at Scitable". www.nature.com. Retrieved 2017-11-29.
- Smýkal, Petr; Varshney, Rajeev K.; Singh, Vikas K.; Coyne, Clarice J.; Domoney, Claire; Kejnovský, Eduard; Warkentin, Thomas (2016-12-01). "From Mendel's discovery on pea to today's plant genetics and breeding" (PDF). Theoretical and Applied Genetics. 129 (12): 2267–2280. doi:10.1007/s00122-016-2803-2. ISSN 0040-5752. PMID 27717955.