The enzyme citramalyl-CoA lyase (EC 4.1.3.25) catalyzes the chemical reaction

citramalyl-CoA lyase
Identifiers
EC no.4.1.3.25
CAS no.37290-68-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
(3S)-citramalyl-CoA acetyl-CoA + pyruvate

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming). Other names in common use include citramalyl coenzyme A lyase, (+)-CMA-CoA lyase, and (3S)-citramalyl-CoA pyruvate-lyase. This enzyme participates in pyruvate metabolism and c5-branched dibasic acid metabolism.

References

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  • Cooper RA, Kornberg HL (1964). "The utilization of itaconate by Pseudomonas sp". Biochem. J. 91 (1): 82–91. PMC 1202819. PMID 4284209.
  • Dimroth P, Buckel W, Loyal R, Eggerer H (1977). "Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase". Eur. J. Biochem. 80 (2): 469–77. doi:10.1111/j.1432-1033.1977.tb11902.x. PMID 923590.