Charles Knox (born 1929) is an American composer.
Charles Knox may also refer to:
- Charles B. Knox (died 1908), founder of the Charles B. Knox Gelatine Co., Inc., husband of Rose Knox
- Charles Edmond Knox (1846–1938), Anglo-Irish soldier of the British Army
- Chuck Knox (1932–2018), football coach
- Sir Charles Knox-Gore, 2nd Baronet (1831–1890) of the Knox-Gore baronets
- Charles Knox (priest) (1770–1825), Archdeacon of Armagh
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