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Carbonic anhydrase III, muscle specific

Carbonic anhydrase 3 is an enzyme that in humans is encoded by the CA3 gene.[5]

Available structures
PDB Ortholog search: PDBe RCSB
Aliases CA3, CAIII, Car3, carbonic anhydrase 3
External IDs MGI: 88270 HomoloGene: 31298 GeneCards: CA3
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for CA3
Genomic location for CA3
Band 8q21.2 Start 85,373,436 bp[1]
End 85,449,040 bp[1]
RNA expression pattern
PBB GE CA3 204865 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 8: 85.37 – 85.45 Mb Chr 3: 14.86 – 14.87 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encode carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue-specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. CA3 is insufficient in muscles of Myasthenia Gravis patients.[6] A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. Autoantibodies to CA3 have been found to be significantly higher in patients with rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.[7] The gene spans 10.3 kb and contains seven exons and six introns.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164879 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027559 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Shima K, Tashiro K, Hibi N, Tsukada Y, Hirai H (Jun 1983). "Carbonic anhydrase-III immunohistochemical localization in human skeletal muscle". Acta Neuropathol. 59 (3): 237–9. doi:10.1007/BF00703210. PMID 6221502. 
  6. ^ Du AL, Ren HM, Lu CZ, Tu JL, Xu CF, Sun YA (Mar 2009). "Carbonic anhydrase III is insufficient in muscles of myasthenia gravis patients". Autoimmunity. 42 (3): 209–15. doi:10.1080/08916930802668610. PMID 19301202. 
  7. ^ Liu C, Wei Y, Wang J, Pi L, Huang J, Wang P (Sep 2012). "Carbonic anhydrases III and IV autoantibodies in rheumatoid arthritis, systemic lupus erythematosus, diabetes, hypertensive renal disease, and heart failure". Clin Dev Immunol. 2012: 354594. doi:10.1155/2012/354594. PMC 3461255 . PMID 23049597. 
  8. ^ "Entrez Gene: CA3 carbonic anhydrase III, muscle specific". 

Further readingEdit