Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene.[5][6]

CPSF7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPSF7, CFIm59, FLJ12529, cleavage and polyadenylation specific factor 7
External IDsMGI: 1917826; HomoloGene: 11731; GeneCards: CPSF7; OMA:CPSF7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136040
NM_001142565
NM_024811

NM_001164272
NM_172302
NM_001362450

RefSeq (protein)

NP_001129512
NP_001136037
NP_079087

NP_001157744
NP_758506
NP_001349379

Location (UCSC)Chr 11: 61.4 – 61.43 MbChr 19: 10.5 – 10.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule used in gene transcription. [7] CPSF7 is one of three Cleavage and polyadenylation specificity factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6).

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149532Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034820Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
  7. ^ Hardy JG, Norbury CJ (August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.

Further reading

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