Dual specificity protein kinase CLK3 is an enzyme that in humans is encoded by the CLK3 gene.[5][6] The CLK3 gene encodes a serine/threonine type protein kinase with a non-conserved N-terminal domain. A long and short isoform (phclk3 and pclk3/152) result from alternative splicing and coexist in different tissues. Isoform phclk3/152 lacks the kinase domain.[7]

CLK3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLK3, PHPHCLK3/152, CDC like kinase 3
External IDsOMIM: 602990; MGI: 1098670; HomoloGene: 101534; GeneCards: CLK3; OMA:CLK3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001130028
NM_001292
NM_003992

NM_007713

RefSeq (protein)

NP_001123500
NP_003983

NP_031739

Location (UCSC)Chr 15: 74.6 – 74.65 MbChr 9: 57.66 – 57.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179335Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032316Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Jan 1995). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". J Mol Biol. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.
  6. ^ Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Dec 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Hum Genet. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. S2CID 40593571.
  7. ^ "Entrez Gene: CLK3 CDC-like kinase 3".

Further reading

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