CLDN7

Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. It belongs to the group of claudins.

CLDN7
Identifiers
Aliases	CLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin 7
External IDs	OMIM: 609131; MGI: 1859285; HomoloGene: 9649; GeneCards: CLDN7; OMA:CLDN7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.1 Start 7,259,903 bp End 7,263,983 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B3 Start 69,855,605 bp End 69,858,711 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon duodenum rectum right uterine tube olfactory zone of nasal mucosa minor salivary glands body of pancreas left lobe of thyroid gland islet of Langerhans right lobe of thyroid gland Top expressed in crypt of lieberkuhn of small intestine left colon migratory enteric neural crest cell ileum duodenum yolk sac medullary collecting duct jejunum mucosa of urinary bladder transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding protein binding cell adhesion molecule binding Cellular component bicellular tight junction cell junction basolateral plasma membrane membrane lateral plasma membrane integral component of membrane apicolateral plasma membrane plasma membrane Biological process negative regulation of protein homooligomerization negative regulation of cell adhesion positive regulation of cell motility negative regulation of apoptotic process positive regulation of cell population proliferation calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1366 53624 Ensembl ENSG00000181885 ENSG00000288292 ENSMUSG00000018569 UniProt O95471 Q9Z261 RefSeq (mRNA) NM_001307 NM_001185022 NM_001185023 NM_001193619 NM_016887 RefSeq (protein) NP_001171951 NP_001171952 NP_001298 NP_001180548 NP_058583 Location (UCSC) Chr 17: 7.26 – 7.26 Mb Chr 11: 69.86 – 69.86 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Claudins, such as CLDN7, are involved in the formation of tight junctions between epithelial cells. Tight junctions restrict lateral diffusion of lipids and membrane proteins, and thereby physically define the border between the apical and basolateral compartments of epithelial cells (Zheng et al., 2003).[supplied by OMIM]

External links

• Human CLDN7 genome location and CLDN7 gene details page in the UCSC Genome Browser.

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
• Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Peacock RE, Keen TJ, Inglehearn CF (1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
• Itoh M, Furuse M, Morita K, et al. (2000). "Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kominsky SL, Argani P, Korz D, et al. (2003). "Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast". Oncogene. 22 (13): 2021–33. doi:10.1038/sj.onc.1206199. PMID 12673207. S2CID 20318884.
• Ban Y, Dota A, Cooper LJ, et al. (2003). "Tight junction-related protein expression and distribution in human corneal epithelium". Exp. Eye Res. 76 (6): 663–9. doi:10.1016/S0014-4835(03)00054-X. PMID 12742348.
• Zheng JY, Yu D, Foroohar M, et al. (2004). "Regulation of the expression of the prostate-specific antigen by claudin-7". J. Membr. Biol. 194 (3): 187–97. doi:10.1007/s00232-003-2038-4. PMID 14502431. S2CID 8482475.
• Resnick MB, Konkin T, Routhier J, et al. (2005). "Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study". Mod. Pathol. 18 (4): 511–8. doi:10.1038/modpathol.3800301. PMID 15475928. S2CID 28512983.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.