Claudin-17 is a protein that in humans is encoded by the CLDN17 gene.[5][6] It belongs to the group of claudins; claudins are cell-cell junction proteins that keep that maintains cell- and tissue-barrier function.[7] It forms anion-selective paracellular channels and is localized mainly in kidney proximal tubules.[8][9]

CLDN17
Identifiers
AliasesCLDN17, claudin 17
External IDsOMIM: 617005; MGI: 2652030; HomoloGene: 8116; GeneCards: CLDN17; OMA:CLDN17 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012131

NM_181490

RefSeq (protein)

NP_036263

NP_852467

Location (UCSC)Chr 21: 30.17 – 30.17 MbChr 16: 88.3 – 88.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156282Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055811Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh M, Katoh M (May 2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int J Mol Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
  6. ^ "Entrez Gene: CLDN17 claudin 17".
  7. ^ Adil, MS; Narayanan, SP; Somanath, PR (2021). "Cell-cell junctions: structure and regulation in physiology and pathology". Tissue Barriers. 9 (1): 1848212. doi:10.1080/21688370.2020.1848212. PMC 7849786. PMID 33300427.
  8. ^ Krug SM, Günzel D, Conrad MP, Rosenthal R, Fromm A, Amasheh S, Schulzke JD, Fromm M (2012). "Claudin-17 forms tight junction channels with distinct anion selectivity". Cell Mol Life Sci. 69 (16): 2765–78. doi:10.1007/s00018-012-0949-x. PMC 11115135. PMID 22402829. S2CID 18173604.
  9. ^ Adil, M; Parvathagiri, V; Verma, A; Liu, F; Rudraraju, M; Narayanan, SP; Somanath, PR (2022). "Claudin-17 Deficiency in Mice Results in Kidney Injury Due to Electrolyte Imbalance and Oxidative Stress". Cells. 11 (11): 1782. doi:10.3390/cells11111782. PMC 9180152. PMID 35681477.
edit

Further reading

edit