CKLF like MARVEL transmembrane domain containing 7

CKLF like MARVEL transmembrane domain-containing 7 (i.e. CMTM7), previously termed chemokine-like factor superfamily 7 (i.e. CKLFSF7), is a protein that in humans is encoded by the CMTM7 gene. This gene, which is located in band 22 on the short (i.e. "p") arm of chromosome 3, and the protein that it encodes belong to the CKLF-like MARVEL transmembrane domain-containing family. Through the process of alternative splicing, the CMTM7 gene encodes two isoforms, CMTM7-v1 and CMTM7-v2, with CMTM7-v1 being the main form expressed and studied. CMTM7 proteins are widely expressed in normal human tissues.[5][6]

CMTM7
Identifiers
AliasesCMTM7, CKLFSF7, CKLF like MARVEL transmembrane domain containing 7
External IDsOMIM: 607890; MGI: 2447166; HomoloGene: 15882; GeneCards: CMTM7; OMA:CMTM7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138410
NM_181472

NM_001252479
NM_133978

RefSeq (protein)

NP_612419
NP_852137

NP_001239408
NP_598739

Location (UCSC)Chr 3: 32.39 – 32.48 MbChr 9: 114.59 – 114.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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CMTM7 protein levels are low in the malignant tissues of various cancers such as those of esophagus, stomach, pancreas, liver, lung, cervix,[5] and breast.[7] as compared with its expression in the normal tissues of these organs.[5][7] Furthermore, the forced overexpression of CMTM7 protein in various cancer immortalized cell lines inhibit their proliferation and motility in culture as well as their ability to form tumors in a nude mouse experimental model of cancer.[8] These findings suggest that the CMTM7 protein acts to inhibit the development and/or progression of these cancers and therefore that the CMTM7 gene acts as tumor suppressor in these cancers.[5] However, further studies are needed to support these suggestion and determine if expression of the CMTM7 can be used as a clinical marker of these cancers severity/prognosis and/or as therapeutic targets for treating them.[5][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153551Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032436Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c d e Wu J, Li L, Wu S, Xu B (August 2020). "CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value". Cancer Biology & Medicine. 17 (3): 528–542. doi:10.20892/j.issn.2095-3941.2020.0032. PMC 7476098. PMID 32944388.
  6. ^ "Entrez Gene: CKLF like MARVEL transmembrane domain-containing 7". Retrieved 2016-03-09.
  7. ^ a b Wu J (2020). "CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma". Cancer Biomarkers. 29 (1): 89–99. doi:10.3233/CBM-191226. PMID 32568178. S2CID 219973219.
  8. ^ Li H, Li J, Su Y, Fan Y, Guo X, Li L, Su X, Rong R, Ying J, Mo X, Liu K, Zhang Z, Yang F, Jiang G, Wang J, Zhang Y, Ma D, Tao Q, Han W (June 2014). "A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth". Oncogene. 33 (24): 3109–18. doi:10.1038/onc.2013.282. PMID 23893243. S2CID 11023199.
  9. ^ Li M, Luo F, Tian X, Yin S, Zhou L, Zheng S (2020). "Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances". Frontiers in Oncology. 10: 595973. doi:10.3389/fonc.2020.595973. PMC 7691587. PMID 33282744.

Further reading

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  • Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D (2003). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–17. doi:10.1016/s0888-7543(03)00095-8. PMID 12782130.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.