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Testis-specific chromodomain protein Y 1 is a protein that in humans is encoded by the CDY1 gene.[2][3]

CDY1
Protein CDY1 PDB 2fbm.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCDY1, CDY, CDY1A, chromodomain protein, Y-linked, 1, chromodomain Y-linked 1
External IDsOMIM: 400016 HomoloGene: 36165 GeneCards: CDY1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004680
NM_170723

n/a

RefSeq (protein)

NP_001003894
NP_001003895

n/a

Location (UCSC)n/an/a
PubMed search[1]n/a
Wikidata
View/Edit Human

This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.[3] The gene is thought to be related to high-altitude adaptation in humans.[4]

ReferencesEdit

  1. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. ^ Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
  3. ^ a b "Entrez Gene: CDY1 chromodomain protein, Y-linked, 1".
  4. ^ Zhang YB, Li X, Zhang F, Wang DM, Yu J (2012). "A preliminary study of copy number variation in Tibetans". PLoS ONE. 7 (7): e41768. Bibcode:2012PLoSO...741768Z. doi:10.1371/journal.pone.0041768. PMC 3402393. PMID 22844521.

External linksEdit

Further readingEdit