Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.[5][6][7]
Function
editCDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.[7]
Interactions
editCDC42EP2 has been shown to interact with CDC42[5][6] and RHOQ.[5]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000149798 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045664 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c Joberty G, Perlungher RR, Macara IG (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Molecular and Cellular Biology. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628. PMID 10490598.
- ^ a b Hirsch DS, Pirone DM, Burbelo PD (Jan 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". The Journal of Biological Chemistry. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
- ^ a b "Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2".
External links
edit- Human CDC42EP2 genome location and CDC42EP2 gene details page in the UCSC Genome Browser.
Further reading
edit- Guru SC, Agarwal SK, Manickam P, Olufemi SE, Crabtree JS, Weisemann JM, Kester MB, Kim YS, Wang Y, Emmert-Buck MR, Liotta LA, Spiegel AM, Boguski MS, Roe BA, Collins FS, Marx SJ, Burns L, Chandrasekharappa SC (Jul 1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Research. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC 310681. PMID 9253601.
- Burbelo PD, Snow DM, Bahou W, Spiegel S (Aug 1999). "MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts". Proceedings of the National Academy of Sciences of the United States of America. 96 (16): 9083–8. Bibcode:1999PNAS...96.9083B. doi:10.1073/pnas.96.16.9083. PMC 17736. PMID 10430899.
- Joberty G, Perlungher RR, Sheffield PJ, Kinoshita M, Noda M, Haystead T, Macara IG (Oct 2001). "Borg proteins control septin organization and are negatively regulated by Cdc42". Nature Cell Biology. 3 (10): 861–6. doi:10.1038/ncb1001-861. PMID 11584266. S2CID 58805.
- Xue Y, Bi F, Zhang X, Zhang S, Pan Y, Liu N, Shi Y, Yao X, Zheng Y, Fan D (Jun 2006). "Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation". International Journal of Cancer. 118 (12): 2965–72. doi:10.1002/ijc.21763. PMID 16395716. S2CID 39137777.
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