Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.[5][6][7]

CDC40
Identifiers
AliasesCDC40, EHB3, PRP17, PRPF17, cell division cycle 40, PCH15
External IDsOMIM: 605585; MGI: 1918963; HomoloGene: 5716; GeneCards: CDC40; OMA:CDC40 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015891

NM_027879

RefSeq (protein)

NP_056975

NP_082155

Location (UCSC)Chr 6: 110.18 – 110.25 MbChr 10: 40.71 – 40.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168438Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038446Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M (Oct 1998). "Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control". RNA. 4 (10): 1304–12. doi:10.1017/S1355838298980712. PMC 1369702. PMID 9769104.
  6. ^ Lindsey LA, Garcia-Blanco MA (Jan 1999). "Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p". J Biol Chem. 273 (49): 32771–5. doi:10.1074/jbc.273.49.32771. PMID 9830021.
  7. ^ a b "Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)".
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Further reading

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