T-complex protein 1 subunit zeta-2 is a protein that in humans is encoded by the CCT6B gene.[5][6][7]

CCT6B
Identifiers
AliasesCCT6B, CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303, chaperonin containing TCP1 subunit 6B
External IDsOMIM: 610730; MGI: 1329013; HomoloGene: 55978; GeneCards: CCT6B; OMA:CCT6B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001193529
NM_001193530
NM_006584

NM_001291242
NM_009839

RefSeq (protein)

NP_001180458
NP_001180459
NP_006575

NP_001278171
NP_033969

Location (UCSC)Chr 17: 34.93 – 34.98 MbChr 11: 82.61 – 82.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a molecular chaperone that is a member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000132141Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020698Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ozaki K, Kuroki T, Hayashi S, Nakamura Y (Jan 1997). "Isolation of three testis-specific genes (TSA303, TSA806, TSA903) by a differential mRNA display method". Genomics. 36 (2): 316–9. doi:10.1006/geno.1996.0467. PMID 8812458.
  6. ^ Kubota H, Hynes GM, Kerr SM, Willison KR (Feb 1997). "Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1" (PDF). FEBS Lett. 402 (1): 53–6. doi:10.1016/S0014-5793(96)01501-3. PMID 9013858. S2CID 1972107.
  7. ^ a b "Entrez Gene: CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)".
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Further reading

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