T-complex protein 1 subunit zeta is a protein that in humans is encoded by the CCT6A gene.[5][6][7]

CCT6A
Identifiers
AliasesCCT6A, CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20, chaperonin containing TCP1 subunit 6A
External IDsOMIM: 104613; MGI: 107943; HomoloGene: 1336; GeneCards: CCT6A; OMA:CCT6A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001762
NM_001009186

NM_009838

RefSeq (protein)

NP_001009186
NP_001753

NP_033968

Location (UCSC)Chr 7: 56.05 – 56.06 MbChr 5: 129.86 – 129.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a molecular chaperone that is member of the TRiC complex. This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[7]

Interactions

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CCT6A has been shown to interact with PPP4C.[8][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000146731Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029447Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Segel GB, Boal TR, Cardillo TS, Murant FG, Lichtman MA, Sherman F (August 1992). "Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA". Proc Natl Acad Sci U S A. 89 (13): 6060–4. Bibcode:1992PNAS...89.6060S. doi:10.1073/pnas.89.13.6060. PMC 49437. PMID 1352881.
  6. ^ Li WZ, Lin P, Frydman J, Boal TR, Cardillo TS, Richard LM, Toth D, Lichtman MA, Hartl FU, Sherman F (August 1994). "Tcp20, a subunit of the eukaryotic TRiC chaperonin from humans and yeast". J Biol Chem. 269 (28): 18616–22. doi:10.1016/S0021-9258(17)32354-2. PMID 8034610.
  7. ^ a b "Entrez Gene: CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)".
  8. ^ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (October 2008). "PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4". J. Biol. Chem. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
  9. ^ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (November 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell. Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
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Further reading

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