Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene.

CCDC90B
Identifiers
AliasesCCDC90B, MDS011, MDS025, coiled-coil domain containing 90B
External IDsMGI: 1913615; HomoloGene: 23328; GeneCards: CCDC90B; OMA:CCDC90B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001162918
NM_025515

RefSeq (protein)

NP_001156390
NP_079791

Location (UCSC)Chr 11: 83.26 – 83.29 MbChr 7: 92.21 – 92.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

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CCDC90B is located on chromosome 11 in humans. It is neighbored by:[5]

  • PCF11, a mammalian pre-mRNA cleavage complex 2 protein
  • ANKRD42, ankyrin repeat protein involved with calcium ion bonding
  • BC070093
  • DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family

Protein

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Structure

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This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.

The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.


Predicted Properties

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Molecular Weight: 26.72 kDa

Isoelectric point: 7.5

Transmembrane Helices: None

Post-translation modifications:[6]

Chloroplast transit peptides: None
Signal pepties: None
C-mannosylation sites: None
N-glycosylation sites: None
Mitochondrial targeting: Yes
Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP

Cellular Location

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CCDC90B is presumably a mitochondrial protein. It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137500Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030613Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "UCSC Genome Bioinformatics BLAT". University of California - Santa Cruz. March 2006. Retrieved 2009-05-14.
  6. ^ "ExPASy". SIB Switzerland. 2009-01-05. Retrieved 2009-05-14.
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