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C2CD4D, or C2 calcium-dependent domain-containing protein 4D is a protein product of the human genome. The gene that codes for this protein is found on chromosome 1, from 150,076,963-150,079,657. The gene contains 2 exons and encodes 353 amino acids. Synonyms for C2CD4D are "FAM148D"[5] and NP_001129475. C2CD4D contains a conserved metal binding domain that is a known as Protein kinase C conserved region 2, subgroup 1. This motif is known to be a member of the C2 superfamily, which is present in phospholipases, protein kinases C, and synaptotagmins.[6] The amino acid sequence of C2CD4D can be accessed at [1] Prior to any post translational modification, C2CD4D has a molecular weight of 37.6 kdal.[7] Although scientists have not yet determined where C2CD4D functions within the cell, C2CD4D has a predicted isoelectric point of 11.636 which severely limits the places in which it can be effective. In addition, C2CD4D does not contain any predicted transmembrane domains or any predicted signal peptides.

AliasesC2CD4D, FAM148D, C2 calcium-dependent domain containing 4D, C2 calcium dependent domain containing 4D
External IDsMGI: 2685505 HomoloGene: 86310 GeneCards: C2CD4D
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for C2CD4D
Genomic location for C2CD4D
Band1q21.3Start151,837,819 bp[1]
End151,840,557 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 151.84 – 151.84 MbChr 3: 94.36 – 94.36 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse


According to the National Center for Biotechnology Information, C2CD4D has only been found to be expressed in adult individuals with some form of cancer.[8] C2CD4D is not ubiquitously expressed, and thus far scientists have only found C2CD4D expressed in the tissues of the brain, intestine, and mammary gland.

Evolutionary conservationEdit

There are 52 known mammalian orthologs for C2CD4D,[9] found in at least 10 species including Pan troglodytes, Ornithorhynchus anatinus, and Sus scrofa. There are a total of 38 completely conserved residues across these 10 species, corresponding to 10.76% conservation. Within vertebrates conservation remains high at 33 residues, corresponding to 9.3%. However, outside of vertebrates, conservation drops to a maximum of 1.98%, or 3 residues.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000225556 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000091648 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "C2 calcium-dependent domain-containing protein 4D [Homo sapiens] - Protein - NCBI".
  6. ^ NCBI
  7. ^ Workbench, NCSA Biology. "SDSC Biology Workbench".
  8. ^ National Center for Biotechnology Information
  9. ^ "NCBI Blast:".
  10. ^ alignment data determined using the ClustalW tool available at and the relevant ortholog results returned from a blast search using the tool available at