Her first on-screen appearance was a role as Grunge Girl in the episode "Team Play" of CBS's medical drama television series Chicago Hope. In 1999, she appeared in several guest starring television roles, including Buffy the Vampire Slayer, ER, Felicity, Popular and Wasteland. She portrayed Teenage Usher in the romantic comedy film Forever Lulu (2000). She has also appeared in films All the Boys Love Mandy Lane (2006), Over Her Dead Body (2008), He's Just Not That Into You (2009), Gabi on the Roof in July (2010) and Ceremony (2010). She portrayed Ronah in the dark drama film She's Lost Control (2014), written and directed by Anja Marquardt. Bloom won "Best Actress" award at the 2014 Thessaloniki International Film Festival for her performance in the film. Marc Adams of Screen International said that there's "much to admire in Marquardt’s control and precision as well as a well sustained lead performance by lead actress Brooke Bloom (...) Brooke Bloom is impressive..."
She portrayed Cynthia Wells in 16 episodes of the police procedural drama television series CSI: Miami. She also had roles in television series Jack & Bobby, Everwood, JAG, In Justice, Good Wife, In Plain Sight, Law & Order, Carpoolers, Person of Interest and The New Normal. In 2017, she played Rebecca Rogers in the Netflix series Gypsy.
|2000||Forever Lulu||Teenage Usher|
|2005||The Search for the Golden Bird||Trudy|
|2006||All the Boys Love Mandy Lane||Cousin Jen|
|2007||The Brothers Solomon||Grocery Shopper|
|2008||Over Her Dead Body||Margaret's Owner|
|2009||He's Just Not That Into You||Paige|
|2009||Five Fingers||Girl||Short film|
|2009||Handjobs for the Future||Sarah||Short film|
|2010||Gabi on the Roof in July||Madeline|
|2010||Five Days Gone||Camden|
|2011||The Key Man||Cheryl|
|2011||Lily Look Here||Lily||Short film|
|2011||Extremely Loud & Incredibly Close||Astrid Black|
|2012||The Normals||Nurse Longley|
|2013||Swim Little Fish Swim||Mary|
|2014||She's Lost Control||Ronah|
|2015||Devil Town||Georgia Newton|
|1999||Chicago Hope||Grunge Girl||Episode: "Team Play"|
|1999||Popular||Teen Girl #1||Episode: "The Phantom Menace"|
|1999||ER||Quinn||Episode: "Truth & Consequences"|
|1999||Felicity||Brent||Episode: "The Love Bug"|
|1999||Buffy the Vampire Slayer||Nicole||Episode: "Hush"|
|1999||Wasteland||N/A||Episode: "Death Becomes Her"|
|2000||City of Angels||Traci Scott / Kelly||Episodes: "Leg Erie", "A Farewell to Arm"|
|2001||Any Day Now||N/A||Episode: "What If?"|
|2003||Cold Case||Tania||Episode: "Our Boy Is Back"|
|2003||JAG||Petty Officer Third Class Anna Farrier||Episode: "Pulse Rate"|
|2004||NYPD Blue||Katie Driscoll||Episode: "You Da Bomb"|
|2004||Jack & Bobby||Bridget||Episode: "Better Days"|
|2004||Everwood||College Guide||Episode: "Shoot the Moon"|
|2004–2009||CSI: Miami||Cynthia Wells||16 episodes|
|2005||Without a Trace||Claire Wallace||Episode: "Safe"|
|2006||In Justice||Rachel||Episode: "Lovers"|
|2007||Eddie & Jeff||Lucy||Episode: "The Colleague"|
|2007||Derek and Simon||Jenny||Episode: "Escape!"|
|2008||Carpoolers||Oola||Episode: "The Handsomest Man"|
|2008||Law & Order||Molly Lasky||Episode: "Pledge"|
|2010||Good Wife||Kate Willoughby||Episode: "Heart"|
|2010||In Plain Sight||Lois Turner||Episode: "No Clemency for Old Men"|
|2013||Person of Interest||Emily Morton||Episode: "One Percent"|
|2013||The New Normal||Debra||Episode: "Blood, Sweat and Fears"|
|2013–2014||Alpha House||Julie Carrell||18 episodes|
|2014||Louie||Young Janet||Episode: "Elevator: Part 4"|
|2015||Law & Order: Special Victims Unit||Dana Farhidi||Episode: "Parents' Nightmare"|
|2016||BrainDead||Abby Summers||2 episodes|
|2016||Falling Water||Sabine||9 episodes|
|2017||Gypsy||Rebecca Rogers||10 episodes|
|2018||New Amsterdam||Millie||Episode: "Rituals"|
- "Brooke Bloom". IMDb. Retrieved 2019-05-28.
- "FNC: She's Lost Control explores sexual surrogacy". Montreal Gazette. 15 October 2014. Retrieved 29 December 2016.
- "Brooke Bloom | TV Guide". TVGuide.com. Retrieved 2019-05-28.
- Filmwax Radio (2018-07-17), BRIC TV / BK Live Interview: Anja Marquardt & Brooke Bloom (SHE'S LOST CONTROL), retrieved 2019-05-28
- Neumaier, Joe. "'She's Lost Control' review: Brooke Bloom rivets as a sex surrogate who deals with wounded souls". latimes.com. Retrieved 2019-05-28.
- "55th TIFF: The Awards". filmfestival.gr. Archived from the original on 2016-03-11. Retrieved 2016-03-11.
- "Review: 'She's Lost Control'". May 9, 2014.
- "'Gypsy' Casts Brooke Bloom As Series Regular, Kimberly Quinn To Recur In Netflix Drama". Deadline. October 4, 2016. Retrieved October 5, 2016.
- Obie Awards, 2015 Winners.