B cell scaffold protein with ankyrin repeats 1

B cell scaffold protein with ankyrin repeats 1 is a protein that in humans is encoded by the BANK1 gene. [5]

BANK1
Identifiers
AliasesBANK1, BANK, B-cell scaffold protein with ankyrin repeats 1, B cell scaffold protein with ankyrin repeats 1
External IDsOMIM: 610292; MGI: 2442120; HomoloGene: 9926; GeneCards: BANK1; OMA:BANK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017935
NM_001083907
NM_001127507

NM_001033350
NM_001310749

RefSeq (protein)

NP_001077376
NP_001120979
NP_060405

NP_001028522
NP_001297678

Location (UCSC)Chr 4: 101.41 – 102.07 MbChr 3: 135.76 – 136.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153064Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037922Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: B cell scaffold protein with ankyrin repeats 1". Retrieved 2018-06-04.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.