BLZF1

Golgin-45 is a protein that in humans is encoded by the BLZF1 gene.

BLZF1
Identifiers
Aliases	BLZF1, GOLGIN-45, JEM-1, JEM-1s, JEM1, basic leucine zipper nuclear factor 1
External IDs	OMIM: 608692; MGI: 1201607; HomoloGene: 31187; GeneCards: BLZF1; OMA:BLZF1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q24.2 Start 169,367,970 bp End 169,396,540 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H2.2 Start 164,117,369 bp End 164,135,058 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gonad buccal mucosa cell epithelium of colon oral cavity mucosa of esophagus gallbladder rectum superficial temporal artery islet of Langerhans Top expressed in lumbar spinal ganglion zygote secondary oocyte esophagus genital tubercle muscle of thigh cardiac muscle tissue of left ventricle neural layer of retina tail of embryo spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity enzyme binding DNA binding protein binding ubiquitin protein ligase binding Cellular component cytoplasm Golgi lumen nucleus Golgi apparatus Golgi membrane membrane nucleoplasm Biological process regulation of transcription by RNA polymerase II Golgi to plasma membrane protein transport protein transport cell population proliferation Golgi organization regulation of cell growth vesicle-mediated transport regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8548 66352 Ensembl ENSG00000117475 ENSMUSG00000026577 UniProt Q9H2G9 Q5T532 Q8R2X8 RefSeq (mRNA) NM_003666 NM_001320972 NM_001320973 NM_001160208 NM_001160209 NM_025505 NM_001357052 RefSeq (protein) NP_001307901 NP_001307902 NP_003657 NP_001153680 NP_001153681 NP_079781 NP_001343981 Location (UCSC) Chr 1: 169.37 – 169.4 Mb Chr 1: 164.12 – 164.14 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

BLZF1 has been shown to interact with GORASP2.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". J. Biol. Chem. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
• Tong JH, Fant X, Duprez E, Benoit G, Uphoff CC, Drexler HG, Pla JC, Lofvenberg E, Lanotte M (1998). "Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells". Leukemia. 12 (11): 1733–40. doi:10.1038/sj.leu.2401173. PMID 9823948.
• Tong JH, Duprez E, Lanotte M (1999). "JEM-1, a novel nuclear co-factor: localisation and functional interaction with AP-1". Leukemia. 13 (12): 1982–92. doi:10.1038/sj/leu/2401560. PMID 10602419.
• Tong JH, Fant X, Benoit G, Chen SJ, Chen Z, Lanotte M (2000). "Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: molecular cloning and analysis of its promoter region". Genomics. 69 (3): 380–90. doi:10.1006/geno.2000.6347. PMID 11056056.
• Short B, Preisinger C, Körner R, Kopajtich R, Byron O, Barr FA (2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401.
• Reichman TW, Muñiz LC, Mathews MB (2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Mol. Cell. Biol. 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746.

External links

• BLZF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human BLZF1 genome location and BLZF1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.