Bcl-2-associated transcription factor 1 is a Bcl-2 family protein in humans that is encoded by the BCLAF1 gene.[5][6][7]

BCLAF1
Identifiers
AliasesBCLAF1, BTF, bK211L9.1, BCL2 associated transcription factor 1
External IDsOMIM: 612588; MGI: 1917580; HomoloGene: 8832; GeneCards: BCLAF1; OMA:BCLAF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077440
NM_001077441
NM_001301038
NM_014739
NM_001363659

NM_001025392
NM_001025393
NM_001025394
NM_153787

RefSeq (protein)

NP_001070908
NP_001070909
NP_001287967
NP_055554
NP_001350588

NP_001020563
NP_001020564
NP_722482

Location (UCSC)Chr 6: 136.26 – 136.29 MbChr 10: 20.31 – 20.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a transcriptional repressor that interacts with several members of the BCL-2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different protein isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000029363Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037608Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  6. ^ Kasof GM, Goyal L, White E (Jun 1999). "Btf, a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins". Mol Cell Biol. 19 (6): 4390–404. doi:10.1128/mcb.19.6.4390. PMC 104398. PMID 10330179.
  7. ^ a b "Entrez Gene: BCLAF1 BCL2-associated transcription factor 1".

Further reading

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