Born in Livorno, he began his career at Piaggio, makers of the Vespa scooter, but quickly moved up to larger engines. He worked at Isotta Fraschini before World War II, and then joined Reggiane to design aircraft engines.
Lampredi's fame brought him to Ferrari in 1946. He temporarily quit the company to go back to Isotta Fraschini in March 1947 but returned to Ferrari at the beginning of 1948 where he designed large 3.3, 4.1 and 4.5 L displacement V12 family of engines (the "Lampredi engine") which first saw use in the 1950s 275 S, 275 F1, 340 F1 and 375 F1 race cars. Lampredi's engines were used as large naturally aspirated alternatives to the diminutive Gioacchino Colombo-designed V12s used in most Ferrari cars until that time. Especially after the failure of Colombo's supercharged engine in Formula One, Lampredi's design began to find favor in the company. Lampredi oversaw Ferrari's racing effort during its early success in 1952 and 1953.
In 1951, Enzo Ferrari saw a good opportunity to make a competitive car for Formula Two racing. And the rules for Formula One made it possible that the Formula Two car could also be competitive in Formula One for two years, until new engine regulations came into effect in 1954. So, he suggested to Lampredi that he design a four cylinder racing engine. This Lampredi twin-cam four cylinder proved very successful in Formula Two, Formula One and sports racing cars.
Lampredi's work at Ferrari ended permanently in 1955 when Ferrari bought Lancia's racing team and famed engine designer Vittorio Jano, formerly of Alfa Romeo. Though Lampredi's engine designs lived on in Ferrari road cars, Jano's V6 and V12 engines quickly replaced Lampredi's large V12s for racing use.
After Ferrari, Lampredi went to Fiat, where he oversaw that company's engine design efforts until 1977. It was at Fiat where he designed the famous Fiat Twin-Cam and SOHC engines, which provided motive-force for most Fiat and Lancia automobiles for over 32 years. He was also made manager of Fiat's Abarth factory racing group from 1973 through 1982.
He was responsible for designing the engine that allowed Fiat to allocate in the Brazilian market in 1976, the FIASA (acronym of Portuguese "Fiat Automóveis S.A). That engine equipped the Fiat 147, direct derivation of the European Fiat 127 but exclusively Brazilian. That was a big impact for the Brazilian automotive industry, because the Fiat 147 was the first national vehicle to have transverse mounted engine with belt driven overhead camshaft. It was also the first engine made on a large scale to be powered by Ethanol. Then, in 1979 the Fiat 147 is known to be the world's first car sold on a large scale to be moved by Ethanol. The Engine went so successful, that Fiat re-used it with small changes in the original project until 2001 (25 years), when the FIASA was superseded by the FIRE engine, also a straight-four engine, but bi-fuelled (Ethanol and Gasoline) and much lighter.
Lampredi died in Livorno in 1989.