Ann or Anne Clarke may refer to:
- Ann Clarke (immunologist), co-founder in 2004 of the Frozen Ark project
- Anne Clarke (theatre producer) (born 1961), Irish theatre producer
- Anne Clarke (theatre manager) (1806–?), Australian stage actor, singer and theatre manager
- Nancy Clarke (entrepreneur) (died 1811/12), Barbadian hotelier and free woman of colour
- Anne Clarke (archaeologist), Australian archaeologist
- Ann M. Clarke (1928–2015), developmental psychologist
- Anne Clarke, American-born British politician from London
See also
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