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Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene.[5][6][7]

AliasesANGPTL1, ANG3, ANGPT3, ARP1, AngY, UNQ162, dJ595C2.2, angiopoietin like 1
External IDsOMIM: 603874 MGI: 1919963 HomoloGene: 128467 GeneCards: ANGPTL1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ANGPTL1
Genomic location for ANGPTL1
Band1q25.2Start178,849,535 bp[1]
End178,871,077 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 178.85 – 178.87 MbChr 1: 156.84 – 156.86 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse



Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels.

The protein encoded by this gene is another member of the angiopoietin family that is widely expressed in adult tissues with mRNA levels highest in highly vascularized tissues. This protein was found to be a secretory protein that does not act as an endothelial cell mitogen in vitro.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116194 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033544 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kim I, Kwak HJ, Ahn JE, So JN, Liu M, Koh KN, Koh GY (Mar 1999). "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett. 443 (3): 353–6. doi:10.1016/S0014-5793(99)00008-3. PMID 10025962.
  6. ^ Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.
  7. ^ a b "Entrez Gene: ANGPTL1 angiopoietin-like 1".

External linksEdit

Further readingEdit