Alpha-isocomene synthase

α-Isocomene synthase (EC 4.2.3.136, MrTPS2) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (–)-α-isocomene-forming).[1] This enzyme catalyses the following chemical reaction

α-isocomene synthase
Identifiers
EC no.4.2.3.136
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
(2E,6E)-farnesyl diphosphate (–)-α-isocomene + diphosphate

This enzyme is isolated from the roots of the plant Matricaria chamomilla var. recutita (chamomile).

References

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  1. ^ Irmisch S, Krause ST, Kunert G, Gershenzon J, Degenhardt J, Köllner TG (June 2012). "The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils". BMC Plant Biology. 12: 84. doi:10.1186/1471-2229-12-84. PMC 3423072. PMID 22682202.
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