All-trans-phytoene synthase (EC 2.5.1.99, prephytoene-diphosphate synthase, phytoene synthetase, PSase, geranylgeranyl-diphosphate geranylgeranyltransferase, 15-trans-phytoene synthase) is an enzyme with systematic name geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase (all-trans-phytoene forming).[1][2] This enzyme catalyses the following chemical reaction
| All-trans-phytoene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.99 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2 geranylgeranyl diphosphate all-trans-phytoene + 2 diphosphate (overall reaction)
- (1a) 2 geranylgeranyl diphosphate diphosphate + prephytoene diphosphate
- (1b) prephytoene diphosphate all-trans-phytoene + diphosphate
This enzyme requires Mn2+ for activity.
References
edit- ^ Gregonis DE, Rilling HC (March 1974). "The stereochemistry of trans-phytoene synthesis. Some observations on lycopersene as a carotene precursor and a mechanism for the synthesis of cis- and trans-phytoene". Biochemistry. 13 (7): 1538–42. doi:10.1021/bi00704a033. PMID 4819767.
- ^ Iwata-Reuyl D, Math SK, Desai SB, Poulter CD (March 2003). "Bacterial phytoene synthase: molecular cloning, expression, and characterization of Erwinia herbicola phytoene synthase". Biochemistry. 42 (11): 3359–65. doi:10.1021/bi0206614. PMID 12641468.
External links
edit- All-trans-phytoene+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
