AlkB homolog 5, RNA demethylase

RNA demethylase ALKBH5 is a protein that in humans is encoded by the ALKBH5 gene.

ALKBH5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NJ4, 4NRM, 4NRO, 4NRP, 4NRQ, 4O61, 4O7X, 4OCT
Identifiers
Aliases	ALKBH5, ABH5, OFOXD, OFOXD1, alkB homolog 5, RNA demethylase
External IDs	OMIM: 613303 MGI: 2144489 HomoloGene: 9818 GeneCards: ALKBH5
Gene location (Human) Chr. Chromosome 17 (human) Band 17p11.2|17p11.2 Start 18,183,078 bp End 18,209,954 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B2 Start 60,427,207 bp End 60,449,338 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle gastrocnemius muscle quadriceps femoris muscle vastus lateralis muscle secondary oocyte body of tongue deltoid muscle parotid gland anterior pituitary right uterine tube Top expressed in retinal pigment epithelium ciliary body cumulus cell iris submandibular gland parotid gland lacrimal gland fossa primitive streak ureter More reference expression data BioGPS n/a
Gene ontology Molecular function 2-oxoglutarate-dependent dioxygenase activity oxidoreductase activity dioxygenase activity metal ion binding oxidative RNA demethylase activity RNA binding mRNA N6-methyladenosine dioxygenase activity Cellular component nuclear speck nucleus nucleoplasm Golgi apparatus cytosol Biological process oxidative single-stranded RNA demethylation mRNA processing cell differentiation response to hypoxia mRNA export from nucleus spermatogenesis DNA dealkylation involved in DNA repair regulation of mRNA stability Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54890 268420 Ensembl ENSG00000091542 ENSMUSG00000042650 UniProt Q6P6C2 Q3TSG4 RefSeq (mRNA) NM_017758 NM_172943 RefSeq (protein) NP_060228 NP_766531 Location (UCSC) Chr 17: 18.18 – 18.21 Mb Chr 11: 60.43 – 60.45 Mb PubMed search
Wikidata
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Further reading

• Thalhammer A, Bencokova Z, Poole R, Loenarz C, Adam J, O'Flaherty L, Schödel J, Mole D, Giaslakiotis K, Schofield CJ, Hammond EM, Ratcliffe PJ, Pollard PJ (2011). "Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)". PLOS ONE. 6 (1): e16210. Bibcode:2011PLoSO...616210T. doi:10.1371/journal.pone.0016210. PMC 3021549. PMID 21264265.
• Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vågbø CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C (2013). "ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility". Mol. Cell. 49 (1): 18–29. doi:10.1016/j.molcel.2012.10.015. PMC 3646334. PMID 23177736.
• Aik W, Scotti JS, Choi H, Gong L, Demetriades M, Schofield CJ, McDonough MA (2014). "Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation". Nucleic Acids Res. 42 (7): 4741–54. doi:10.1093/nar/gku085. PMC 3985658. PMID 24489119.
• Feng C, Liu Y, Wang G, Deng Z, Zhang Q, Wu W, Tong Y, Cheng C, Chen Z (2014). "Crystal structures of the human RNA demethylase Alkbh5 reveal basis for substrate recognition". J. Biol. Chem. 289 (17): 11571–83. doi:10.1074/jbc.M113.546168. PMC 4002068. PMID 24616105.
• Xu C, Liu K, Tempel W, Demetriades M, Aik W, Schofield CJ, Min J (2014). "Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation". J. Biol. Chem. 289 (25): 17299–311. doi:10.1074/jbc.M114.550350. PMC 4067165. PMID 24778178.
• Du T, Rao S, Wu L, Ye N, Liu Z, Hu H, Xiu J, Shen Y, Xu Q (2015). "An association study of the m6A genes with major depressive disorder in Chinese Han population". J Affect Disord. 183: 279–86. doi:10.1016/j.jad.2015.05.025. PMID 26047305.
• Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL (2016). "Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA". Proc. Natl. Acad. Sci. U.S.A. 113 (14): E2047–56. Bibcode:2016PNAS..113E2047Z. doi:10.1073/pnas.1602883113. PMC 4833258. PMID 27001847.