Acyl-coa synthetase medium chain family member 2a

Acyl-CoA synthetase medium chain family member 2A is a protein that in humans is encoded by the ACSM2A gene. [5]

ACSM2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACSM2A, A-923A4.1, ACSM2, acyl-CoA synthetase medium-chain family member 2A, acyl-CoA synthetase medium chain family member 2A
External IDsOMIM: 614358; MGI: 2385289; HomoloGene: 70404; GeneCards: ACSM2A; OMA:ACSM2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001010845
NM_001308169
NM_001308172
NM_001308954

NM_001177977
NM_001177978
NM_146197

RefSeq (protein)

NP_001295098
NP_001295101
NP_001295883

NP_001171448
NP_001171449
NP_666309

Location (UCSC)Chr 16: 20.45 – 20.49 MbChr 7: 119.15 – 119.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183747Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030945Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Acyl-CoA synthetase medium chain family member 2A". Retrieved 2018-07-10.

Further reading

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  • Kochan G, Pilka ES, von Delft F, Oppermann U, Yue WW (May 2009). "Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A". J. Mol. Biol. 388 (5): 997–1008. doi:10.1016/j.jmb.2009.03.064. PMID 19345228.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.