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Abraham Zangen

Abraham Zangen (Hebrew: אברהם צנגן, born 1969)[1] is an Israeli professor of neuroscience, head of the brain stimulation and behavior lab and chair of the psychobiology brain program at Ben-Gurion University of the Negev (BGU).[2]

Abraham Zangen
Born1969 (age 54–55)
Jerusalem, Israel
CitizenshipIsraeli
SpouseRachel
Children6
Scientific career
InstitutionsWeizmann Institute of Science; Ben Gurion University of the Negev

Biography edit

Abraham Zangen was born in Ramat Gan, Israel.[3] He earned his B.Sc. in pharmacology from the Hebrew University and his PhD from the Bar Ilan University in Israel in 1999.[2] He then did a postdoc at the U.S. National Institutes of Health (NIH) until 2003.[1] In 2003, he returned to Israel and established a laboratory at the Weizmann Institute of Science in Rehovot, attaining the rank of associate professor in 2010. In 2012, he joined the faculty of Ben Gurion University of the Negev and was made a full professor in 2015.[2]

Zangen is married to Rachel, with whom he has six children.[4]

Scientific career edit

Zangen studies neuroplasticity in the brain reward system and the effects of brain stimulation on neuroplasticity in psychiatric disorders including depression, addiction and attention deficits.[5]

During his postdoc at the NIH, Zangen was part of a team that invented a magnetic coil called the "H coil" for use in transcranial magnetic stimulation (TMS); the coil allows deeper penetration of the magnetic field into the brain and the procedure wherein the H-coil was applied to TMS became known as "Deep TMS".[1][6][7][8] The H-coil was patented by the NIH in 2002, and was licensed by the startup company Brainsway in 2003.[9][10] Zangen has continued to do research on applications for Deep TMS and consults for BrainsWay.[5][11]

At the National Institute on Drug Abuse in Baltimore, Zangen worked on reward processing on animal models and learned that electrical stimulation of a rat's brain can induce neurochemical changes opposite of those induced by repeated exposure to cocaine. In 2007, then at the Weizmann Institute of Science, Zangen published the first study showing that brain stimulation in rats can reduce drug-seeking behavior, and began to develop applications of these animal studies to humans.[12]

The MIT Technology Review reported that Zangen and his team were evaluating the potential for disrupting areas of the brain that are overactive in cases of addiction or Obsessive compulsive disorder (OCD).[13]

In 2018, the FDA granted de novo clearance to deep transcranial magnetic stimulation as a non-invasive treatment for OCD, after being cleared for treatment-resistant major depressive disorder in 2013 following multicenter studies conducted by Zangen and his team.[14]

In 2020, the FDA granted clearance for a different version of this technology for smoking cessation in the wake of another multicenter study.[15][16]

As of April 2021, over 100,000 patients around the world have been treated with Deep TMS.[17]

In 2023, a comparative study led by Zangen validated the efficacy of two different Deep TMS coils for treatment-resistant depression.[18] The study also indicated clinical and electrophysiological features that can be used to select the best coil for a given patient. According to Zangen, this study was an "important scientific step forward towards personalized psychiatry."[19] Zangen has been working with BrainsWay on a multichannel stimulation device that can target multiple regions of the brain in different ways, exciting some regions and suppressing others.[12]

Zangen has published over 150 peer-reviewed articles, reviews and book chapters.[20]

Awards and recognition edit

Zangen has won prizes for his scientific achievements,[21][22] among them the Medical Futures Innovation Award in the field of Mental Health and Neuroscience, UK, in 2007,[23] the Sieratzki Prize for Advances in Neuroscience in 2010,[24] the Juludan Research Prize in 2015 [25] and the annual Innovation Award of Ben Gurion University in 2019.[26]

Selected papers edit

  • Zangen, A; Ikemoto, Satoshi; Zadina, James E.; Wise, Roy A. (2002-08-15). "Rewarding and Psychomotor Stimulant Effects of Endomorphin-1: Anteroposterior Differences within the Ventral Tegmental Area and Lack of Effect in Nucleus Accumbens". Journal of Neuroscience. 22 (16): 7225–7233. doi:10.1523/jneurosci.22-16-07225.2002. PMC 6757872. PMID 12177217.
  • Zangen, A; Solinas, Marcello; Ikemoto, Satoshi; Goldberg, Steven R.; Wise, Roy A. (2006-05-03). "Two Brain Sites for Cannabinoid Reward". Journal of Neuroscience. 26 (18): 4901–4907. doi:10.1523/JNEUROSCI.3554-05.2006. PMC 6674153. PMID 16672664.
  • Zangen, A; Roth, Yiftach; Voller, Bernhard; Hallett, Mark (2005). "Transcranial magnetic stimulation of deep brain regions: evidence for efficacy of the H-Coil". Clinical Neurophysiology. 116 (4): 775–779. doi:10.1016/j.clinph.2004.11.008. PMID 15792886. S2CID 25101101.
  • Dinur-Klein, Limor; Dannon, Pinhas; Hadar, Aviad; Rosenberg, Oded; Roth, Yiftach; Kotler, Moshe; Zangen, Abraham (2014). "Smoking Cessation Induced by Deep Repetitive Transcranial Magnetic Stimulation of the Prefrontal and Insular Cortices: A Prospective, Randomized Controlled Trial". Biological Psychiatry. 76 (9): 742–749. doi:10.1016/j.biopsych.2014.05.020. PMID 25038985. S2CID 6232377.
  • Carmi, Lior; Alyagon, Uri; Barnea-Ygael, Noam; Zohar, Joseph; Dar, Reuven; Zangen, Abraham (2018). "Clinical and electrophysiological outcomes of deep TMS over the medial prefrontal and anterior cingulate cortices in OCD patients". Brain Stimulation. 11 (1): 158–165. doi:10.1016/j.brs.2017.09.004. PMID 28927961. 
  • Levkovitz, Y; Isserles, Moshe; Padberg, Frank; Lisanby, Sarah H.; Bystritsky, Alexander; Xia, Guohua; Tendler, Aron; Daskalakis, Zafiris J.; Winston, Jaron L. (2015-02-01). "Efficacy and safety of deep transcranial magnetic stimulation for major depression: a prospective multicenter randomized controlled trial". World Psychiatry. 14 (1): 64–73. doi:10.1002/wps.20199. PMC 4329899. PMID 25655160.
  • Naim-Feil, Jodie; Zangen, Abraham (2013). "Chapter 49: Addiction". In Lozano, Andres M.; Hallett, Mark (eds.). Brain Stimulation. Elsevier Inc. ISBN 9780128080559.
  • Zangen, A.; Zibman, S.; Tendler, A.; Barnea-Ygael, N.; Alyagon, U.; Blumberger, D. M.; Grammer, G.; Shalev, H.; Gulevski, T.; Vapnik, T.; Bystritsky, A.; Filipčić, I.; Feifel, D.; Stein, A.; Deutsch, F.; Roth, Y.; George, M. S. (2023). "Pursuing personalized medicine for depression by targeting the lateral or medial prefrontal cortex with Deep TMS". JCI Insight. 8 (4). doi:10.1172/jci.insight.165271. PMC 9977507. PMID 36692954.

See also edit

References edit

  1. ^ a b c Rapp, David (17 February 2005). "Field of Dreams". Haaretz.
  2. ^ a b c "CV and Publications". Zangen lab at Ben-Gurion University of the Negev. Archived from the original on 20 January 2018. Retrieved 20 January 2018.
  3. ^ Helmet for a Good Head, Makor Rishon
  4. ^ A Beautiful Magnetic Mind
  5. ^ a b Abraham Zangen's Lab
  6. ^ Bersani, F.S.; Minichino, A.; Enticott, P.G.; Mazzarini, L.; Khan, N.; Antonacci, G.; Raccah, R.N.; Salviati, M.; Chiai e, R. Delle (2013). "Deep transcranial magnetic stimulation as a treatment for psychiatric disorders: A comprehensive review". European Psychiatry. 28 (1): 30–39. doi:10.1016/j.eurpsy.2012.02.006. PMID 22559998. S2CID 29053871.
  7. ^ George, Mark S. (September 2003). "Stimulating the Brain". Scientific American. 289 (3): 66–73. Bibcode:2003SciAm.289c..66G. doi:10.1038/scientificamerican0903-66. PMID 12951829.
  8. ^ "A Beautiful Magnetic Mind". Weizmann Weizmann Institute of Science Wonder Wander. 1 May 2005.
  9. ^ Blackburn, Nicky (19 February 2006). "Israel's Brainsway stimulates a magnetic remedy for depression". Israel21c. Retrieved 11 January 2013.
  10. ^ "Magnetic Stimulation Shows Promise as the New Wave for Treating Depression". NIH Office of Technology Transfer. 24 July 2007. Archived from the original on 30 March 2013.
  11. ^ Chu, Jennifer (May 19, 2008). "A Gentler Way to Jump-Start the Brain". MIT Technology Review.
  12. ^ a b Makin, Simon (2023). "Brain-zapping technology helps smokers to quit". Nature. 618 (7964): S7–S9. Bibcode:2023Natur.618S...7M. doi:10.1038/d41586-023-01839-8. PMID 37286653. S2CID 259093812.
  13. ^ A gentler way to jumpstart the brain, MIT Technology Review
  14. ^ US FDA clears first magnetic non-invasive device treatment for OCD
  15. ^ FDA clears first brain stimulation device for smoking cessation
  16. ^ Jerusalem medtech company BrainsWay wins FDA approval to treat smoking, Jerusalem Post
  17. ^ BrainsWay Announces 100,000 Patients Treated with Deep Transcranial Magnetic Stimulation (Deep TMS)
  18. ^ Pursuing personalized medicine for depression by targeting lateral or medial prefrontal cortex with deep TMS
  19. ^ Publication Analyzes Clinical Efficacy of Deep TMS in Treating Different Brain Regions Associated with Major Depressive Disorder, Nature.com
  20. ^ BrainsWay:Abraham Zangen, PhD
  21. ^ "Dr. Abraham Zangen - News, Features and Discoveries from the Weizmann Institute of Science". Weizmann Wonder Wander. 2007-09-02. Retrieved 2018-01-04.
  22. ^ "Ben-Gurion University of the Negev - Prof. Abraham Zangen wins Juludan Research Prize". in.bgu.ac.il. Retrieved 2018-01-04.
  23. ^ Weizmann Wonder Wander
  24. ^ The Sieratzki Family and Tel Aviv University: Prize Winners
  25. ^ Prof. Abraham Zangen wins Juludan Research Prize
  26. ^ פרס מחקר יישומי פורץ דרך לפרופ' אברהם צנגן

External links edit

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