Atonal bHLH transcription factor 8 is a protein that in humans is encoded by the ATOH8 gene.[5] It is hypothesized to play a role endochondral ossification as a regulator of chondrocyte proliferation and differentiation.[6] In addition, it also participates in the chondrogenesis of limb bud mesenchymal progenitor cells.[7]
References
edit- ^ a b c GRCh38: Ensembl release 89: ENSG00000168874 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037621 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Atonal bHLH transcription factor 8". Retrieved 2016-10-19.
- ^ Schroeder, Nadine; Wuelling, Manuela; Hoffmann, Daniel; Brand-Saberi, Beate; Vortkamp, Andrea (2019-08-26). van Wijnen, Andre (ed.). "Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones". PLOS ONE. 14 (8): e0218230. Bibcode:2019PLoSO..1418230S. doi:10.1371/journal.pone.0218230. ISSN 1932-6203. PMC 6709907. PMID 31449527.
- ^ Takács, Roland; Vágó, Judit; Póliska, Szilárd; Pushparaj, Peter Natesan; Ducza, László; Kovács, Patrik; Jin, Eun-Jung; Barrett-Jolley, Richard; Zákány, Róza; Matta, Csaba (2023-03-29). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. ISSN 1362-4962. PMC 10164575. PMID 36987858.
Further reading
edit- Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
- Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
- Chen J, Dai F, Balakrishnan-Renuka A, Leese F, Schempp W, Schaller F, Hoffmann MM, Morosan-Puopolo G, Yusuf F, Bisschoff IJ, Chankiewitz V, Xue J, Chen J, Ying K, Brand-Saberi B (2011). "Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor". PLOS ONE. 6 (8): e23005. Bibcode:2011PLoSO...623005C. doi:10.1371/journal.pone.0023005. PMC 3150394. PMID 21857980.
- Güttsches AK, Balakrishnan-Renuka A, Kley RA, Tegenthoff M, Brand-Saberi B, Vorgerd M (2015). "ATOH8: a novel marker in human muscle fiber regeneration". Histochem. Cell Biol. 143 (5): 443–52. doi:10.1007/s00418-014-1299-6. PMID 25514850. S2CID 9753058.
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