As any top Italian water polo club, Pescara has written in golden letters her own great stories both in the domestic and even more in the competitive European competitions. Crowning achievement of the club so far consists the winning of 1988 LEN Champions League over against the mighty West German team of the 80's, Spandau 04, closely followed by the multiple wins of Italian Cups and LEN Cup Winners' Cups in the second period of its golden age in the middle '90s. The 1996 LEN Trophy was Pescara's last major European win before the long-awaited climbing to the top of the Italian league for two consecutive years in 1997 and 1998. Throughout, the aforementioned period is characterized by Pescara's continuous unsuccessful attempt to throw off Savona and mostly Posillipo from the throne of Serie A1 and LEN Champions League. In 1998 Pescara tried to double its European leagues (ten years after the first time) but defeated 8-6 in the final by its great rival and last European Champion, Posillipo. Also this was a unique chance to make the triple crown achievement.
In the 2000s the club has experienced a slow decline in sports and corporate, losing participation in the European Cup and then to the top flight. At the beginning of the 2009-10 season AS Waterpolis Pescara announced its failure and the withdrawal from all domestic and international leagues.
In water polo team of Pescara have played Olympic and world champions, and, in general, the great names of Italian and foreign water polo as the brothers Roberto and Alessandro Calcaterra, Marco D'Altrui, Amedeo Pomilio, Francesco Attolico and Spaniard Manuel Estiarte.
- Winners (1): 1987-88
- Runners-up (1): 1997-98
- Winners (3): 1989-90, 1992–93, 1993–94
- Runners-up (1): 1994-95
- Winners (1): 1995-96
- Winners (2): 1988, 1993
- Runners-up (2): 1990, 1994
- Winners (3): 1986-87, 1996–97, 1997–98
- Winners (5): 1984-85, 1985–86, 1988–89, 1991–92, 1997–98
- Chiude Water Polis. Pescara, pallanuoto addio, Waterpoloweb.com, 5 dicembre 2009.