Apolipoprotein M is an apolipoprotein and member of the lipocalin protein family that in humans is encoded by the APOM gene.[5][6][7] It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized.[7] It lacks an external amphipathic motif and is uniquely secreted to plasma without cleavage of its terminal signal peptide.[8] The average molecular weight is 21253 Da, and the monoisotopic molecular weight is 21239 Da.

APOM
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPOM, G3a, HSPC336, NG20, apo-M, apolipoprotein M
External IDsOMIM: 606907; MGI: 1930124; HomoloGene: 10308; GeneCards: APOM; OMA:APOM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256169
NM_019101

NM_018816

RefSeq (protein)

NP_001243098
NP_061974

NP_061286

Location (UCSC)Chr 6: 31.65 – 31.66 MbChr 17: 35.35 – 35.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ApoM
Identifiers
SymbolApoM
PfamPF11032
Pfam clanCL0116
InterProIPR022734
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

References

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  1. ^ a b c ENSG00000204444, ENSG00000206409, ENSG00000227567, ENSG00000235754, ENSG00000224290, ENSG00000226215 GRCh38: Ensembl release 89: ENSG00000231974, ENSG00000204444, ENSG00000206409, ENSG00000227567, ENSG00000235754, ENSG00000224290, ENSG00000226215Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024391Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xu N, Dahlbäck B (October 1999). "A novel human apolipoprotein (apoM)". The Journal of Biological Chemistry. 274 (44): 31286–31290. doi:10.1074/jbc.274.44.31286. PMID 10531326.
  6. ^ Duan J, Dahlbäck B, Villoutreix BO (June 2001). "Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis". FEBS Letters. 499 (1–2): 127–132. doi:10.1016/S0014-5793(01)02544-3. PMID 11418126. S2CID 28493816.
  7. ^ a b "Entrez Gene: APOM apolipoprotein M".
  8. ^ Christoffersen C, Ahnström J, Axler O, Christensen EI, Dahlbäck B, Nielsen LB (July 2008). "The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma". The Journal of Biological Chemistry. 283 (27): 18765–18772. doi:10.1074/jbc.M800695200. PMID 18460466.

Further reading

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