APOL6

APOL6
Identifiers
Aliases	APOL6, APOL-VI, APOLVI, apolipoprotein L6
External IDs	OMIM: 607256 MGI: 1919189 HomoloGene: 49940 GeneCards: APOL6
Gene location (Human)
Chr.	Chromosome 22 (human)
End	35,668,404 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,941,306 bp
RNA expression pattern
	Top expressed in
	pericardium; ; pylorus; ; sperm; ; monocyte; ; human penis; ; vena cava; ; cardia; ; palpebral conjunctiva; ; trigeminal ganglion; ; trachea;
	Top expressed in
	white adipose tissue; ; subcutaneous adipose tissue; ; soleus muscle; ; brown adipose tissue; ; mammary gland; ; skeletal muscle tissue; ; intercostal muscle; ; thoracic diaphragm; ; tibialis anterior muscle; ; gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	lipid binding;
Cellular component	extracellular region; cytoplasm;
Biological process	lipoprotein metabolic process; lipid transport;
	Sources:Amigo / QuickGO
Orthologs
	80830
	71939
	ENSG00000221963
	ENSMUSG00000033576
	Q9BWW8
	n/a
	NM_030641
	NM_001163621; NM_028010
	NP_085144
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene.^[5]^[6]^[7]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221963 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033576 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
^ Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (Jan 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells". Mol Cancer Res. 3 (1): 21–31. doi:10.1158/1541-7786.21.3.1. PMID 15671246. S2CID 2545675.
^ ^a ^b "Entrez Gene: APOL6 apolipoprotein L, 6".

External links edit

Human APOL6 genome location and APOL6 gene details page in the UCSC Genome Browser.

Further reading edit

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Dominguez O, Ashhab Y, Sabater L, et al. (1999). "Cloning of ARE-containing genes by AU-motif-directed display". Genomics. 54 (2): 278–86. doi:10.1006/geno.1998.5548. PMID 9828130.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221963 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033576 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11374903-5] Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.

[pmid15671246-6] Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (Jan 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells". Mol Cancer Res. 3 (1): 21–31. doi:10.1158/1541-7786.21.3.1. PMID 15671246. S2CID 2545675.

[entrez-7] "Entrez Gene: APOL6 apolipoprotein L, 6".

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