DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.[3][4][5]

APOBEC3F
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesAPOBEC3F, A3F, ARP8, BK150C2.4.MRNA, KA6, apolipoprotein B mRNA editing enzyme catalytic subunit 3F
External IDsOMIM: 608993; HomoloGene: 105867; GeneCards: APOBEC3F; OMA:APOBEC3F - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001006666
NM_145298

n/a

RefSeq (protein)

NP_001006667
NP_660341

n/a

Location (UCSC)Chr 22: 39.04 – 39.06 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128394Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
  4. ^ Holmes RK, Koning FA, Bishop KN, Malim MH (Jan 2007). "APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G". J Biol Chem. 282 (4): 2587–95. doi:10.1074/jbc.M607298200. PMID 17121840.
  5. ^ a b "Entrez Gene: APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F".

Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. Zheng YH, Irwin D, Kurosu T, Tokunaga K, Sata T, Peterlin BM. J Virol. 2004 Jun;78(11):6073-6. doi: 10.1128/JVI.78.11.6073-6076.2004.

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Further reading

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