Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.[3][4]

APOBEC3D
Identifiers
AliasesAPOBEC3D, A3D, APOBEC3DE, APOBEC3E, ARP6, apolipoprotein B mRNA editing enzyme catalytic subunit 3D, A3DE
External IDsOMIM: 609900; HomoloGene: 122788; GeneCards: APOBEC3D; OMA:APOBEC3D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_152426
NM_001363781

n/a

RefSeq (protein)

NP_689639
NP_001350710

n/a

Location (UCSC)Chr 22: 39.02 – 39.03 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.[4]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243811Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (Feb 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics. 79 (3): 285–96. doi:10.1006/geno.2002.6718. PMID 11863358.
  4. ^ a b "Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)".

Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family. Dang Y, Wang X, Esselman WJ, Zheng YH. J Virol. 2006 Nov;80(21):10522-33. doi: 10.1128/JVI.01123-06. Epub 2006 Aug 18.

edit

Further reading

edit