AMP—thymidine kinase

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In enzymology, an AMP—thymidine kinase (EC 2.7.1.114) is an enzyme that catalyzes the chemical reaction

AMP-thymidine kinase
Identifiers
EC no.2.7.1.114
CAS no.60440-28-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
AMP + thymidine adenosine + thymidine 5'-phosphate

Thus, the two substrates of this enzyme are AMP and thymidine, whereas its two products are adenosine and thymidine 5'-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is AMP:thymidine 5'-phosphotransferase. This enzyme is also called adenylate-nucleoside phosphotransferase.

References

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  • Falke D, Labenz J, Brauer D, Muller WE (1982). "Adenosine diphosphate: thymidine 5'-phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus-induced deoxypyrimidine kinase". Biochim. Biophys. Acta. 708 (1): 99–103. doi:10.1016/0167-4838(82)90207-2. PMID 6293576.
  • Falke D, Nehrbass W, Brauer D, Muller WE (1981). "Adenylic acid: deoxythymidine 5'-phosphotransferase: evidence for the existence of a novel herpes simplex virus-induced enzyme". J. Gen. Virol. 53 (Pt 2): 247–55. doi:10.1099/0022-1317-53-2-247. PMID 6267178.