ALDH3B1

ALDH3B1
Identifiers
Aliases	ALDH3B1, ALDH4, ALDH7, aldehyde dehydrogenase 3 family member B1
External IDs	OMIM: 600466 MGI: 1914939 HomoloGene: 73890 GeneCards: ALDH3B1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	68,029,282 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,979,808 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; monocyte; ; right lung; ; thoracic diaphragm; ; olfactory bulb; ; upper lobe of left lung; ; trachea; ; tibial nerve; ; vena cava;
	Top expressed in
	spermatid; ; right lung lobe; ; duodenum; ; seminiferous tubule; ; jejunum; ; adrenal gland; ; spermatocyte; ; carotid body; ; proximal tubule; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	3-chloroallyl aldehyde dehydrogenase activity; protein binding; oxidoreductase activity; aldehyde dehydrogenase [NAD(P)+ activity]; aldehyde dehydrogenase (NAD+) activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;
Cellular component	vesicle; membrane; plasma membrane; extracellular exosome; secretory granule membrane; specific granule membrane; cytoplasm; cytosol;
Biological process	ethanol catabolic process; lipid metabolism; aldehyde catabolic process; sphingolipid biosynthetic process; cellular aldehyde metabolic process; cellular response to oxidative stress; metabolism; alcohol metabolic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	221
	67689
	ENSG00000006534
	ENSMUSG00000024885
	P43353; Q9BUJ8
	Q80VQ0
	NM_001290059; NM_000694; NM_001030010; NM_001161473; NM_001290058
	NM_026316
	NP_000685; NP_001025181; NP_001154945; NP_001276987; NP_001276988
	NP_080592
	Wikidata
View/Edit Human	View/Edit Mouse

Aldehyde dehydrogenase 3 family, member B1 also known as ALDH3B1 is an enzyme that in humans is encoded by the ALDH3B1 gene.^[5]^[6]

Function edit

The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene encodes a single transcript of 2.8 kb that is highly expressed in kidney and lung. The functional significance of this gene and the cellular localization of its product are presently unknown. Two transcript variants encoding different isoforms have been found for this gene.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000006534 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024885 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hsu LC, Chang WC, Yoshida A (Dec 1994). "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene. 151 (1–2): 285–9. doi:10.1016/0378-1119(94)90672-6. PMID 7828891.
^ Hsu LC, Chang WC, Yoshida A (Apr 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID 9161417.
^ "Entrez Gene: ALDH3B1".

External links edit

Human ALDH3B1 genome location and ALDH3B1 gene details page in the UCSC Genome Browser.

Further reading edit

Sun X, Jia Y, Zhang X, Xu Q, Shen Y, Li Y (Jun 2005). "Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method". Science in China Series C: Life Sciences. 48 (3): 263–9. doi:10.1007/bf03183620. PMID 16092759. S2CID 19136391.
Hsu LC, Chang WC, Yoshida A (Dec 1994). "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene. 151 (1–2): 285–9. doi:10.1016/0378-1119(94)90672-6. PMID 7828891.
Marchitti SA, Orlicky DJ, Vasiliou V (May 2007). "Expression and initial characterization of human ALDH3B1". Biochemical and Biophysical Research Communications. 356 (3): 792–8. doi:10.1016/j.bbrc.2007.03.046. PMC 1899873. PMID 17382292.
Saito A, Kawamoto M, Kamatani N (Jun 2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". Journal of Human Genetics. 54 (6): 317–23. doi:10.1038/jhg.2009.31. PMID 19343046.
Wang Y, Hu Y, Fang Y, Zhang K, Yang H, Ma J, Xu Q, Shen Y (Jun 2009). "Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia". Biological Psychiatry. 65 (12): 1048–54. doi:10.1016/j.biopsych.2008.11.027. PMID 19159868. S2CID 25166866.
Yoshida A, Rzhetsky A, Hsu LC, Chang C (Feb 1998). "Human aldehyde dehydrogenase gene family". European Journal of Biochemistry. 251 (3): 549–57. doi:10.1046/j.1432-1327.1998.2510549.x. PMID 9490025.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000006534 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024885 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7828891-5] Hsu LC, Chang WC, Yoshida A (Dec 1994). "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene. 151 (1–2): 285–9. doi:10.1016/0378-1119(94)90672-6. PMID 7828891.

[pmid9161417-6] Hsu LC, Chang WC, Yoshida A (Apr 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID 9161417.

[entrez-7] "Entrez Gene: ALDH3B1".

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