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10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.[5]

ALDH1L1
Protein ALDH1L1 PDB 1s3i.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesALDH1L1, 10-FTHFDH, 10-fTHF, FDH, FTHFD, aldehyde dehydrogenase 1 family member L1
External IDsMGI: 1340024 HomoloGene: 122031 GeneCards: ALDH1L1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ALDH1L1
Genomic location for ALDH1L1
Band3q21.3Start126,103,562 bp[1]
End126,197,994 bp[1]
RNA expression pattern
PBB GE ALDH1L1 205208 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270364
NM_001270365
NM_012190

NM_027406
NM_001356412

RefSeq (protein)

NP_001257293
NP_001257294
NP_036322

NP_081682
NP_001343341

Location (UCSC)Chr 3: 126.1 – 126.2 MbChr 6: 90.49 – 90.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. The encoded protein belongs to the aldehyde dehydrogenase family and is responsible for formate oxidation in vivo. Deficiencies in this gene can result in an accumulation of formate and subsequent methanol poisoning.[5]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144908 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030088 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: ALDH1L1 aldehyde dehydrogenase 1 family, member L1".

External linksEdit

Further readingEdit