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Aldehyde dehydrogenase 1 family, member A2, also known as ALDH1A2 or retinaldehyde dehydrogenase 2 (RALDH2), is an enzyme that in humans is encoded by the ALDH1A2 gene.[5][6]

ALDH1A2
Protein ALDH1A2 PDB 1bi9.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesALDH1A2, RALDH(II), RALDH2, RALDH2-T, aldehyde dehydrogenase 1 family member A2
External IDsOMIM: 603687 MGI: 107928 HomoloGene: 68368 GeneCards: ALDH1A2
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for ALDH1A2
Genomic location for ALDH1A2
Band15q21.3Start57,953,424 bp[1]
End58,497,866 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_170697
NM_001206897
NM_003888
NM_170696

NM_009022

RefSeq (protein)

NP_001193826
NP_003879
NP_733797
NP_733798

NP_033048

Location (UCSC)Chr 15: 57.95 – 58.5 MbChr 9: 71.22 – 71.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a paracrine hormone signaling molecule that functions in developing and adult tissues.[7] The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels that facilitate posterior organ development and prevent spina bifida. Three transcript variants encoding distinct isoforms have been identified for this gene.[6]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128918 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013584 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ono Y, Fukuhara N, Yoshie O (Dec 1998). "TAL1 and LIM-Only Proteins Synergistically Induce Retinaldehyde Dehydrogenase 2 Expression in T-Cell Acute Lymphoblastic Leukemia by Acting as Cofactors for GATA3". Mol Cell Biol. 18 (12): 6939–50. PMC 109277. PMID 9819382.
  6. ^ a b "Entrez Gene: ALDH1A2 aldehyde dehydrogenase 1 family, member A2".
  7. ^ Duester G (September 2008). "Retinoic Acid Synthesis and Signaling during Early Organogenesis". Cell. 134 (6): 921–31. doi:10.1016/j.cell.2008.09.002. PMC 2632951. PMID 18805086.

External linksEdit

Further readingEdit