Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.[5][6]

AGTRAP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAGTRAP, ATRAP, angiotensin II receptor associated protein
External IDsOMIM: 608729; MGI: 1339977; HomoloGene: 7621; GeneCards: AGTRAP; OMA:AGTRAP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040194
NM_001040195
NM_001040196
NM_001040197
NM_020350

NM_001301281
NM_009642

RefSeq (protein)

NP_001035284
NP_001035285
NP_001035286
NP_001035287
NP_065083

NP_001288210
NP_033772

Location (UCSC)Chr 1: 11.74 – 11.75 MbChr 4: 148.16 – 148.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.[6]

Interactions

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AGTRAP has been shown to interact with GNB2L1.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177674Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029007Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (Dec 2001). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)". Int J Biochem Cell Biol. 34 (1): 93–102. doi:10.1016/S1357-2725(01)00094-2. PMID 11733189.
  6. ^ a b "Entrez Gene: AGTRAP angiotensin II receptor-associated protein".
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Further reading

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