Aftiphilin is a protein that in humans is encoded by the AFTPH gene.[5][6][7] It forms a stable complex with p200 and synergin gamma.[6][7] It contains a clathrin box with two known clathrin-binding sequence motifs, is involved in vesicle trafficking[8] and is found in many eukaryotes.

AFTPH
Identifiers
AliasesAFTPH, Nbla10388, aftiphilin
External IDsMGI: 1923012; HomoloGene: 9764; GeneCards: AFTPH; OMA:AFTPH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002243
NM_017657
NM_203437

NM_001252503
NM_001290545
NM_181411

RefSeq (protein)

NP_001239432
NP_001277474
NP_852076

Location (UCSC)Chr 2: 64.52 – 64.59 MbChr 11: 20.64 – 20.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Clathrin-binding box of Aftiphilin
Identifiers
SymbolClathrin_bdg
PfamPF15045
InterProIPR029205
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119844Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049659Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS (Feb 2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains". J Biol Chem. 279 (9): 8018–28. doi:10.1074/jbc.M311873200. PMID 14665628.
  6. ^ a b Hirst J, Borner GH, Harbour M, Robinson MS (Apr 2005). "The aftiphilin/p200/gamma-synergin complex". Mol Biol Cell. 16 (5): 2554–65. doi:10.1091/mbc.E04-12-1077. PMC 1087257. PMID 15758025.
  7. ^ a b Burman JL, Wasiak S, Ritter B, de Heuvel E, McPherson PS (Apr 2005). "Aftiphilin is a component of the clathrin machinery in neurons". FEBS Lett. 579 (10): 2177–84. doi:10.1016/j.febslet.2005.03.008. PMID 15811338. S2CID 23970781.
  8. ^ Lui-Roberts WW, Ferraro F, Nightingale TD, Cutler DF (December 2008). "Aftiphilin and gamma-synergin are required for secretagogue sensitivity of Weibel-Palade bodies in endothelial cells". Mol. Biol. Cell. 19 (12): 5072–81. doi:10.1091/mbc.E08-03-0301. PMC 2592662. PMID 18815278.
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Further reading

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