Aminoacylase-1 is an enzyme that in humans is encoded by the ACY1 gene.[5][6][7]

ACY1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACY1, ACY-1, ACY1D, HEL-S-5, aminoacylase 1
External IDsOMIM: 104620; MGI: 87913; HomoloGene: 110440; GeneCards: ACY1; OMA:ACY1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001198898
NM_000666
NM_001198895
NM_001198896
NM_001198897

NM_001276442
NM_025371

RefSeq (protein)

NP_000657
NP_001185824
NP_001185825
NP_001185826
NP_001185827

NP_001263371
NP_079647

Location (UCSC)Chr 3: 51.98 – 51.99 MbChr 9: 106.31 – 106.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000243989Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023262Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miller YE, Drabkin H, Jones C, Fisher JH (Sep 1990). "Human aminoacylase-1: cloning, regional assignment to distal chromosome 3p21.1, and identification of a cross-hybridizing sequence on chromosome 18". Genomics. 8 (1): 149–154. doi:10.1016/0888-7543(90)90237-O. PMID 1707030.
  6. ^ Voss R, Lerer I, Povey S, Solomon E, Bobrow M (Jul 1980). "Confirmation and further regional assignment of aminoacylase 1 (acy-1) on human chromosome 3 using a simplified detection method". Annals of Human Genetics. 44 (Pt 1): 1–9. doi:10.1111/j.1469-1809.1980.tb00940.x. PMID 6948533. S2CID 21566170.
  7. ^ a b "Entrez Gene: ACY1 aminoacylase 1".
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Further reading

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