Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.[5][6][7][8][9]

ACOT8
Identifiers
AliasesACOT8, HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE, NAP1, acyl-CoA thioesterase 8
External IDsOMIM: 608123 MGI: 2158201 HomoloGene: 3991 GeneCards: ACOT8
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005469
NM_183385
NM_183386

NM_133240
NM_001362756
NM_001362757

RefSeq (protein)

NP_005460

NP_573503
NP_001349685
NP_001349686

Location (UCSC)Chr 20: 45.84 – 45.86 MbChr 2: 164.79 – 164.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.[9]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101473 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017307 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jones JM, Nau K, Geraghty MT, Erdmann R, Gould SJ (Apr 1999). "Identification of peroxisomal acyl-CoA thioesterases in yeast and humans". J Biol Chem. 274 (14): 9216–23. doi:10.1074/jbc.274.14.9216. PMID 10092594.
  6. ^ Liu LX, Margottin F, Le Gall S, Schwartz O, Selig L, Benarous R, Benichou S (Jul 1997). "Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation". J Biol Chem. 272 (21): 13779–85. doi:10.1074/jbc.272.21.13779. PMID 9153233.
  7. ^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
  8. ^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
  9. ^ a b "Entrez Gene: ACOT8 acyl-CoA thioesterase 8".

Further readingEdit

External linksEdit