Alpha/beta hydrolase domain containing 3 (ABHD3; alternative names: lung alpha/beta hydrolase 3,[5] phospholipase ABHD3) is a single pass type II membrane member of the serine hydrolase family of enzymes.[6] The expression of murine ABHD3 is highest in the brain, liver, and kidney. ABHD3 hydrolytic activity is highly specific for medium chain (e.g., dimyristoylphosphatidylcholine) and oxidatively truncated (e.g., azelaoyl PAF) phospholipids. ABHD3-deficient mice are viable, fertile, and possess dramatically elevated medium chain phospholipids in tissues and in blood. Conversely, ectopic expression of ABHD3 prevents the accumulation of oxidized phospholipids in cells.

ABHD3
Identifiers
AliasesABHD3, LABH3, abhydrolase domain containing 3, abhydrolase domain containing 3, phospholipase
External IDsOMIM: 612197; MGI: 2147183; HomoloGene: 14055; GeneCards: ABHD3; OMA:ABHD3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308256
NM_001308257
NM_138340

NM_134130

RefSeq (protein)

NP_001295185
NP_001295186
NP_612213

NP_598891

Location (UCSC)Chr 18: 21.65 – 21.7 MbChr 18: 10.64 – 10.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158201Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002475Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Edgar AJ, Polack JM (Apr 2002). "Cloning and tissue distribution of three murine alpha/beta hydrolase fold protein cDNAs". Biochem Biophys Res Commun. 292 (3): 617–25. doi:10.1006/bbrc.2002.6692. PMID 11922611.
  6. ^ Long JZ, Cisar JS, Milliken D, Niessen S, Wang C, Trauger SA, Suizdak G, Cravatt BF (Sep 2011). "Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids". Nature Chemical Biology. 7 (11): 763–5. doi:10.1038/nchembio.659. PMC 3201731. PMID 21926997.