February 15 – 145,095 confirmed cases of COVID-19 and 2,953 deaths since the beginning of the pandemic.
March 6 – President Benitez asks his entire cabinet to resign following conflicts between demonstrators and police at protests against the government’s handling of the COVID-19 pandemic. Rioters threw stones at police, who responded with rubber bullets and tear gas on March 5. More than 165,800 cases of COVID-19 have been reported, resulting in 3,200 deaths.
March 12 – Andrés Gubetich, head of the Instituto de Previsión Social (IPS), resigns amidst scandal related to a lack of vaccines and overly-restrictive hospital admission requirements. Health Minister Julio Mazzoleni also resigns. Paraguay has reported 174,013 cases and 3,387 deaths from COVID-19, with the highest number of cases in Asunción.