|1740s in South Africa|
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- Henri Guillaume Bossau, founder of the Boshoff family in South Africa and great-grandfather of Jacobus Nicolaas Boshoff, 2nd state president of the Orange Free State, arrives in Cape Town from Bayonne, France as a locksmith in the service of the Dutch East India Company.
- 25 January — Adriaan Valckenier, Governor-General of the Dutch East India Company, is arrested in Cape Town on sundry charges.
- The Governor-General of the Dutch East India Company, Von Imhoff visits Cape Town.
- Simon's Bay is chosen to be used as a harbour between mid-May and mid-August because of the damage caused by the winter storms in Table Bay.
- A Dutch Reformed Church is established in Roodezand, today known as Tulbagh.
- 5 March — Georg Schmidt, the first Protestant missionary in South Africa, who worked with the Khoikhoi, returns to Europe.
- The Dutch East India Company established a magistracy at Swellendam.
- The Dutch Reformed Church establish a congregation in the Swartland, Malmesbury.
- 1743 — Jan de la Fontaine, Governor of the Cape Colony.
- Ansorge, Isabelle J.; Brundrit, Geoff; Brundrit, Jean; Dorrington, Rosemary A.; Fawcett, Sarah; Gammon, David W.; Henry, Tahlia; Hermes, Juliet; Hölscher, Beate; d’Hotman, Jethan; Meiklejohn, Ian (2016-09-23). "SEAmester – South Africa's first class afloat". South African Journal of Science. 112 (9/10). doi:10.17159/sajs.2016/a0171. ISSN 0038-2353.