(3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphatase (EC 3.1.3.52, branched-chain oxo-acid dehydrogenase phosphatase, branched-chain 2-keto acid dehydrogenase phosphatase, branched-chain α-keto acid dehydrogenase phosphatase, BCKDH', [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase, [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphate phosphohydrolase) is an enzyme with systematic name (3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphate phosphohydrolase.[1][2] This enzyme catalyses the following chemical reaction
| (3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring))-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.52 | ||||||||
| CAS no. | 88086-29-7&title= 87244-20-0, 88086-29-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] phosphate + H2O [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)] + phosphate
This mitochondrial enzyme is associated with the 3-methyl-2-oxobutanoate dehydrogenase complex.
References
edit- ^ Fatania HR, Patston PA, Randle PJ (July 1983). "Dephosphorylation and reactivation of phosphorylated purified ox-kidney branched-chain dehydrogenase complex by co-purified phosphatase". FEBS Letters. 158 (2): 234–8. doi:10.1016/0014-5793(83)80585-7. PMID 6307746.
- ^ Reed LJ, Damuni Z, Merryfield ML (1985). "Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation". Current Topics in Cellular Regulation. 27: 41–9. PMID 3004826.
External links
edit- (3-methyl-2-oxobutanoate+dehydrogenase+(2-methylpropanoyl-transferring))-phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
