Zilliacus is a Finland-Swedish surname that may refer to
- Benedict Zilliacus (born 1921), Finnish journalist, author, scriptwriter and translator
- Bruno Zilliacus (1877–1926), Finnish athlete
- Jutta Zilliacus (born 1925), Finnish-born Estonian journalist, author and ex-member of parliament
- Konni Zilliacus (senior) (1855–1924), Finnish politician, author and independence activist
- Konni Zilliacus (1894–1967), Finnish-born British member of parliament
- Tobias Zilliacus (born 1971), Finnish actor
- Thomas Zilliacus (born 1954), Finnish businessman
- Linda Zilliacus (born 1977 as Linda Gyllenberg), Finnish actress