Zapotillo may refer to:
- Zapotillo, Ecuador, town in Ecuador, capital of the Zapotillo Canton
- Zapotillo Canton, canton in Loja Province, Ecuador
- Zapotillo, Panama, corregimiento in Las Palmas District, Veraguas Province, Panama
- Zapotillo River, river in Mexico
This disambiguation page lists articles about distinct geographical locations with the same name.
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