Zampieri is an Italian surname. Notable people with the surname include:
- Caio Zampieri (born 1986), Brazilian tennis player
- Daniel Zampieri (born 1990), Italian racing driver
- Domenico Zampieri (1581–1641), known as Domenichino, Italian painter
- Gian Luigi Zampieri, Italian conductor
- Mara Zampieri (born 1951), Italian opera singer
- Steve Zampieri (born 1977), Swiss cyclist